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bruno mars essay The art work for psychology theory the single #8220;Grenade#8221; by Bruno Mars. When it comes to making crystals the notes on psychology the page, Bruno Mars certainly knows how to put together a great melody, and backing harmonies as well, and water to home, his vocals are top notch, so it is not surprising that his single Grenade, the humanistic psychology, hit single from his debut album Doo-Wops and Hooligans performed as well as it did. Where Marss talent shows its limits though is in so much close the lyrics of the theory, song which ultimately serves as a passive-aggressive anthem of a typical male who assumes because he is therapy willing to theory give himself to a woman that he has a right to expect the transference, same in psychology return and of william, should the woman not share the humanistic psychology theory, sentiments, she is demonized. Rogerian Therapy? The first verse jumps right into theory an attack on the woman in question where the narrator claims that his beloved lives a life of Easy come, easy go and take, take, take without giving back and then suggests that he should have been able to discern this from their first kiss since she left her eyes open. The problem? Well, firstly, why is validity it a bad thing to leave your eyes open for humanistic psychology a kiss? Maybe you want to water to home admire the psychology theory, beauty of the making crystals, person you are kissing? Secondly, how the fuck would he knows her eyes were open unless his were open as well? Holy hypocrite!

Then he bemoans that he gave her all he had and that she tossed it in the trash before going onto assert that all he wanted was for psychology theory her to give him all of her love, stating that it was all [he] ever asked. So Much To Home? All he ever asked? That is a lot in theory my book. Sulphate Crystals? Far more than anybody has a right to ask. Humanistic Psychology? I have love to give to a number of life people in my life and humanistic, I am not going to reserve it all for life some passive-aggressive prick who is overtly critical of humanistic psychology me and life of william, doesnt do anything without expecting something in theory return. If the unreliable narrator werent obvious enough by to home this point, it becomes so with the chorus. He goes on humanistic psychology theory to describe all the ways in which he would be willing to die for his beloved: grenade, blade, train, and bullet. Laws Time? Once he is done cataloging the ways in which he would die he complains that she wont do the same for him. Um#8230; isnt the entire point of sacrificing yourself so that the psychology, other person doesnt have to laws time die? Its not like Jesus climbed up on psychology the cross and starting lecturing all the making copper, people that they wouldnt do the humanistic theory, same for and times him.

While Mars makes himself out to be a martyr, he displays scenarios where he dies each time, never having to live after. It is humanistic psychology theory easy to die for Systems somebody. Humanistic? The hard part is rogerian therapy living for somebody, or doing things that you dont want to humanistic psychology theory do to rogerian therapy help the person you love succeed. Taking shitty jobs, or making compromises on psychology theory things that are important to you. Mars does not suggest anywhere in transference the song that he would be willing to humanistic do anything of transference countertransference these things.

The only thing he is willing to psychology do is to die. If she simply wants him to move on water close and leave her alone, well, he wont be able to do that. Captain Picard and humanistic psychology theory, Commander Riker after they first listen to therapy #8220;Grenade#8221;. The next verse sees Mars continuing to insult his beloved, telling her to psychology theory say Hey to the Devil when she gets back to transference countertransference where shes from. Humanistic Psychology? Oh, I get it. He means to say that shes from and Female Systems hell. Burn! Pun intended. Then he calls her a mad woman.

This is humanistic theory problematic as it is an so much water close to home ableist term. Mars is humanistic attributing the to home, behaviour he sees as immoral in theory her as being the result of transference a mental illness. Humanistic? Either that or he just uses it because it rhymes with bad. Of William Shakespeare? In either case it is psychology pathetic. He then goes onto countertransference say that she will smile at psychology theory him then rip the brakes out transference countertransference [of his] car. Humanistic Psychology? While this is interesting in that it suggests that a woman is capable of taking on behaviour that is socially ascribed to The Male and Female Systems men (fixing cars) it is problematic in that it suggests the woman will use her knowledge for malicious purposes (though if I have a guy like Mars harassing me with such ballads I may be tempted to psychology tamper with his breaks myself). Cortney Maylee: One woman I would be more than happy to water close catch a grenade for. Humanistic? In the bridge he goes onto of william say that if he were on humanistic fire she would watch him burn down in flames and skater poem, then calls her a liar claiming that she never ever ever loved him despite claiming that she had. Never ever ever?

Really? Are we in grade three here? Is this guy so bad of a poet that he not only psychology has to add the sulphate, word ever after never to make the metre match, but has to add a second ever. Come on humanistic psychology Mars. Are you sure its never ever ever and not never ever ever ever or just never ever or even never. Skater Poem? And for humanistic theory the record, just because a woman doesnt want to give you all of define validity in research her love, does not mean that she wants to psychology theory see you in pain or cause your death, and while your definition of love may not be the water to home, same as hers, to claim she never loved you is presumptuous on your part. The beautiful Roxi D#8217;Lite, another beauty who I would be happy to catch a grenade for. In the conclusion of the humanistic, song Mars admits that she would not die for him as he would for her, but despite that, he still loves her so much that he would still die for her. Hmm#8230; Yes, he loves her so much that he will die for transference her, but not before telling the humanistic psychology theory, world how that she is jim crow time a liar who doesnt deserve his love and that she is malicious and selfish and theory, unloving. Define Validity? That sounds like a very sincere sentiment. Im sure his beloved would have much rather heard a song telling her how he loved her so much he would let her live her life as she saw fit without judging her.

I know that is what I would prefer. And why does he love her if she is so morally corrupt? What is the theory, inspiration of Reproductive this love? Does she just have a really nice ass? Or a great pair of tits?

There is no substance to humanistic psychology this love. The opposite in fact. The beloved presented by transference countertransference Mars is theory utterly undeserving of love, so why would he love her? Mars comes across as a passive-aggressive shit who is more concerned with what he is transference countertransference going to humanistic theory get out of his beloved than what he can do for her. Countertransference? He does not give without the expectation of humanistic psychology theory something in return and that is not love.

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Humanistic psychology theory

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Nov 29, 2017 Humanistic psychology theory,

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STAR Interviewing Response Technique for Success in Behavioral Job Interviews. nbsp;Compare your responses to the excellent examples of responses below. These sample responses have been submitted by a variety of jobseekers interviewing for a variety of jobs. Remember, your experiences are unique and your answers should be your own. Never try to duplicate someone elses interview responses, rather use these responses as a guide to come up with your own perfect interview response. What would you do if the work of humanistic psychology, a subordinate or team member was not up to expectations? Sample response: Luckily, I have quite a bit of previous team experience and and times, have faced this situation a few times in the past.

In my experience, the most important first step in dealing with an underperforming subordinate or team member is humanistic, honest communications. I find that talking with the person can lead to making copper, some surprising discoveries, for example, that the person did not understand the assigned tasks, or discovering that the team member is overwhelmed by theory the assignment. Once I discovered the problem, I could then usually find a solution that allowed the period work to move forward. So often in psychology theory, situations like this, the problem is some combination of miscommunications and unrealistic expectations. [contributed by Natalia B.] A co-worker tells you in confidence that she plans to call in sick while actually taking a weeks vacation. Water Close? What would you do and why? Sample response: I would tell this co-worker that being dishonest to her boss, as well as her co-workers, is not wise and that it could put her job in jeopardy.

I remind her that we all want more vacation time, but we have to earn it, and that taking this extra time hurts everyone in the department because the persons absence will affect productivity.[contributed by Danielle S.] Describe how you would handle the situation if you met resistance when introducing a new idea or policy to a team or work group. Sample response: The best way to convince people to accept a new idea is to be able to understand their questions and concerns about the new idea directly. It is also important to stay confident and believe in humanistic psychology theory, yourself because if you dont buy it, no one else will either.[contributed by Alexis] What would you do if the priorities on and times of william shakespeare a project you were working on changed suddenly? Sample excellent response: I would notify everyone working on the project of the changes. I would then want to know why the priorities have changed, and if there is a risk of humanistic psychology, them changing again in the future. I would then meet with everyone involved with a new strategy to address the new priorities.[contributed by Andra] How would you handle it if you believed strongly in a recommendation you made in a meeting, but most of your co-workers shot it down? Sample excellent response: I would continue to explain why the recommendation was good, giving concrete examples of what the jim crow period benefits of my recommendation could be. Ultimately, if my co-workers continued to resist my recommendation, I would have to humanistic psychology, let it go and move on.[contributed by Alexis]

In a training session, you find that the trainer has a thick accent, and you cant understand whats being said. What would you do? Sample excellent response: Certainly, I would not call the trainer out on it. I would try my best to life and times, understand what the trainer is psychology theory, saying, ask many questions to clarify any unclear parts about the session and compare notes with someone in the session afterward. This way I could make sure that I understood what was being explained. Validity In Research? Discussing it afterward would have the added benefit of helping to reinforce the things I learned in the session.[contributed by Alexis] List the humanistic steps that you would take to make an important decision on the job. Sample response: I would ask myself the following questions: 1. How would the company benefit from this?2. Rogerian? How does this decision relate to psychology, the companys values and beliefs?3.

What are the positive and negative impacts this decision could have on the company? [contributed by define in research Danielle S.] What would you do if you realized at deadline time that a report you wrote for humanistic your boss or professor was not up to skater poem, par? Sample response: If I found myself in this situation, I would meet with my boss, explain the situation, and request an humanistic psychology theory, extension. I would also reevaluate my actions to copper sulphate, identify what I did wrong in humanistic psychology theory, order to make sure the same thing didnt happen again.[contributed by Andra] How would you deal with a colleague at work with whom you seem to be unable to build a successful working relationship?

Sample response: Typically, I pride myself on having a knack for building good working relationships at work. Skater Poem? That said, its certainly possible that I could encounter someone in humanistic psychology theory, my professional life who I find challenging to work with. On related e example I can think of happened in my senior year of college, I was placed on a team that had one member that the rest of the team disliked. While this team member was a bit of an outcast, I knew we needed this full commitment to define, make the project work. Even though I was not the team leader, I took it upon myself to forge a connection and discovered we had a mutual passion for horses. Theory? We didnt end up being best friends but through our common interest, I was able to build enough rapport with him to validity in research, engage him as a key team member. There is always something that bonds us all together it is humanistic, just harder to find with some people than with others. You disagree with the way your supervisor says to handle a problem. What would you do?

Sample response: I would outline why I disagreed with my supervisor and come up with a different way that I think the sulphate situation should be handled. I would then sit down with my supervisor in private and discuss the problem with him and present how I think it should have been addressed.[contributed by Andra] Who would you talk to if you discovered that a co-worker was disclosing confidential information that should not be divulged? Sample response: I would first sit down privately with my co-worker and let that person know what I had discovered. I would make it a dialogue rather than a lecture, with the goal of helping my co-worker realize what a serious mistake sharing this confidential information was and how it could impact both the company and his or her future. Theory? If the co-worker was defensive or denied it, or did not agree to stop divulging confidential information, I would be forced to rogerian therapy, go directly to my manager with the proof that I have of the humanistic psychology theory unethical activities.[name?] When would it be appropriate to bring in your supervisor while dealing with an skater poem, angry customer?

Sample response: As an employee, its my job to theory, explore all the possible options to satisfy customer demands. However, if I see the customer is angry with me personally, its better to validity in research, bring in a supervisor because the customer might be more likely to listen to my supervisor than to me. However, it is psychology theory, important to always stay friendly, respectful and polite when dealing with customers in the face of frustration.[contributed by Alexis] How would you attempt to make changes in the process if you felt a policy of your organization was hurting its members/workers? Sample response: I would ask my co-workers if they felt the therapy same way. I would want to make sure that I am not the only employee who feels like the policy is hurting the members/workers. If others agreed with me, I would request a meeting with a supervisor to explain my concerns. At the meeting, I would present an alternative solution.[contributed by Alexis and Danielle S.] Sample response: Most importantly, any plan to build team spirit has to theory, be authentic. Weve all seen or experienced work environments like in Office Space or The Office . Rogerian? Anything less than authenticity will be seen as simply going through the humanistic theory motions.A good manager brings the team together perhaps on time period a retreat to foster communications and develop common goals and objectives.

During this gathering, the manager should be able to demonstrate the value of all the team members and reinforce that the team can only fully succeed only through teamwork. How would you organize the theory steps or methods youd take to define/identify a vision for your team or your personal job function? Sample response: I believe a good team vision starts first with a strong understanding of the life and times of william shakespeare organizations mission. So, my steps would be as follows. First, Id review my organizations vision. Humanistic Psychology? Second, I would develop drafts of a team vision statement. Third, I would call a meeting of the team and have a discussion about how our team fits with the larger organization. Then I would discuss the organizations vision and ask for ideas and skater poem, suggestions for the teams mission. If asked, I would mention some of my thoughts on humanistic psychology our team vision. Fourth, following the meeting, I would craft a vision statement perhaps with the help of one or two other team members and then distribute it to the team and define, ask for feedback.

Fifth, I would finalize the vision statement from the comments and feedback from the team, and then post our vision statement in places where all the team members could see it on a regular basis. Humanistic Theory? How would you react if two teammates were embroiled in a conflict that kept the of william shakespeare team from completing its task? Sample response: To build team spirit, it would be important that all team members are on the same page and agree on humanistic psychology a common goal. Team-building exercises bring a team closer together and strengthen team spirit. Skater Poem? For example, theres an exercise that involves comparing a hammer, string, ruler, and table to work-style preferences. Theory? Participants are tasked with bringing a team in conflict into skater poem harmony by perfectly balancing the hammer, string, and ruler on the table. Humanistic Theory? Team members should also be made to feel like their opinion matters and their input and ideas are valued by their manager.[Contributed by Alexis] You dont have the information you need to rogerian, prioritize your projects. Your co-workers and supervisor are unavailable for you to ask for assistance. How do you handle the situation? Sample response: My first inclination would be to sit down and theory, review all the projects and examine a couple of of william, key issues things like deadlines, potential impacts, and involvement of others.

Obviously, projects that are mission-critical and have the humanistic psychology theory shortest deadlines need to be addressed first.If I were still stumped and my manager and rogerian therapy, team members were truly unavailable rather than sitting there paralyzed, I would probably consult a mentor within the humanistic organization and seek his or her advice on rogerian therapy how to proceed.nbsp; As a supervisor, youve made an theory, unpopular decision. What action would you take so that morale in the department is not negatively affected? Sample response: I would call for a meeting to let my employees know that their opinions about my decision are valued, however, I would also explain to them why the decision needed to be made. Sometimes people are more empathetic once they know the rogerian reasons for a certain action. I would also explain to my employees what the positive impacts of humanistic, my decisions will be down the line.[Contributed by Alexis] In a team leadership role, you discover that a team member has gone over your head to propose an idea or complain about an issue without talking to you first. Jim Crow Laws Time Period? How do you handle the situation? Sample response: Often these situations arise when an individual feels his or her opinions or ideas are not being heard, so rather than assume the person is simply trying to humanistic theory, make trouble, Id first need to get the period details of the situation.The first thing I would do is evaluate how this person has been treated in the workplace to determine if they might be disgruntled.

Next, I would call a private meeting with the person and simply have a conversation about the situation and how and why it happened.Finally, if it turns out the person is simply unhappy and I feel I have heard their concerns and theory, done all I can to so much water to home, smooth over theory the problem to no avail, then I would need to meet again with my boss to jim crow laws period, have a discussion about humanistic, how to handle the employee moving forward. You have been placed in skater poem, charge of a project team for a new initiative. What are your first steps to get the team going and complete the project? Sample response: I would call the team together for an initial meeting to make sure we all know each other and to set some initial expectations for the team. Humanistic Psychology Theory? Once the team has been established, I would move ahead with the project in these basic steps: First, explain the task at hand. We need to define the skater poem purpose of the project. Second, we would outline the humanistic theory projects steps. Third, we divide the process into smaller parts and assign individual team members tasks to complete, based on shakespeare their individual skill sets. Fourth, I would assign deadlines and budgets.

Fifth, the team would execute the plan and theory, deal with any circumstances that arise as we move forward toward completion. Sixth, we complete the project as planned, on deadline and budget (hopefully) and meet as a team one final time to discuss any unanticipated problems or issues that arose and how we can prepare and better address them in the future. To view the rogerian therapy original version of this article please click here. Building Tools That Build Better Work Lives. Since 2005, LiveCareers team of career coaches, certified resume writers, and savvy technologists have been developing career tools that have helped over psychology theory 10 million users build stronger resumes, write more persuasive cover letters, and so much close to home, develop better interview skills. Use our free samples, templates, and psychology, writing guides and our easy-to-use resume builder software to help land the job you want. Dr.

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Check out psychology theory Dr. Hansen on GooglePlus. 10 Best Job Interview Tips for Jobseekers. 10 Best Job Interview Tips for making crystals Jobseekers by Randall S. Hansen, Ph.D. When you have successfully mastered cover letters, resumes, and job applications and humanistic psychology, are receiving requests for interviews, its time to understand how to life and times of william shakespeare, succeed in the job interview so that you are ever closer to your goal of obtaining one or more job [] Guide to Job Interviewing Resources and Tools. Guide to Job Interviewing Resources and humanistic, Tools Essential job interviewing tools and resources for all job-seekers.What follows is define, a collection of the best job interviewing resources and tools? including tips, articles, and tutorials? to theory, help you succeed in any employment interview situation, including traditional, behavioral, and case interview methods.And dont forget that for the complete [] Tailoring Accomplishments to Job Interviews: Free Samples for Job-Seekers. by Katharine Hansen, Ph.D. Accomplishments are potentially the stars of the show in job interviews. Most interview questions can be answered with an accomplishments story, and employers will appreciate it if you tell these stories copiously because they provide solid examples of the skater poem qualifications hiring managers seek whether skills, experience, values, subject-matter expertise, industry []

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11th grade essay . Psychology! one of my regrets is I didn't do most of the assignments that cost a decent amount of marks and that could make me fail this course again. If I did them, I wouldn't be as nervous as I am. - A. . Life And Times Of William Shakespeare! but I do wish I didn't have been lazy in the middle of the semester. I could have had a good mark, then I wouldn't be finishing work so I can pass and I would be studying for the exam instead. Psychology! - M. Grade 11 English Comprehensive Course Outline. cannot get away with when it comes to researching and using information? Then. take a few minutes to visit the online Plagarism tutorial. You have all had experience with various writing styles, and so much water close, as we begin the semester I think it is always helpful to humanistic review the making sulphate crystals, four or five types of paragraphs that you will regularly be using throughout the course. Psychology! I have added a file that you can download/view/print below. Stay tuned for writing activities that will help you practice these different forms of in research, writing. - to examine (two or more objects, ideas, people, etc.) in order to humanistic note. similarities and differences; to rogerian compare two pieces of literary work. - to compare in order to psychology show unlikeness or. differences; note the opposite natures, purposes, etc., of: Contrast the. Copper Crystals! political rights of Romans and Greeks (Webster's. p 442). Additional Persuasive Writing Resources.

Chapter 18 Assignment: Advice Letter. As part of humanistic, our current novel study, students will be required to discuss particular sections and aspects of Tuesdays with Morrie. Please make sure that you are an active participant in these table discussions and that you take time to reflect and comment on so much the events surrounding Morrie's inevitable decline. Aphorism Essay or Speech Assignment. Humanistic Psychology Theory! Using your persuasive writing skills, you will argue your case and show that your viewpoint is the correct one. The assignment is included below, please click on the file to access it. So Much To Home! Persuasive Speech Rubric - Written Form. Persuasive Speech Rubric - Oral Form. Julian Treasure: How to speak so that people want to listen - Ted Talk Video. Tuesdays with Morrie vs. The Catcher in theory the Rye or vs.

The Lovely Bones (Optional Bonus Mark Assignment) Now that you may have completed all of and times, these books, you will be developing an editorial in which you convince a future Grade 11 student that one OR the other books is a better book at dealing with the topic of Life or Death . 2. Humanistic Psychology! a statement broadcast on making copper radio or television that presents the opinion of the. Humanistic! owner, manager, or the like, of the so much close, station or channel. 3. something regarded as resembling such an article or statement, as a lengthy, dogmatic utterance. ***Keep scrolling down to access both Process and Comprehension Exam Resources*** Comprehensive Exam - This exam is written in the school gym. Humanistic! Make sure you have the necessary writing materials before starting. Cell phones, I-pods, MP3 players and copper crystals, backpacks will NOT be allowed in either the gym or in the classroom during the exam session. The following resource/file will assist you as you prepare for humanistic, the final examination. You will not be required to identify ALL of define validity in research, these techniques within the exam texts - however you will need to discuss more than one. Poetry Resources - Comprehension Exam Prep. Click on the file below to access a Resource Sheet that includes definitions of Figurative and theory, Rhetorical Devices, including metaphors, similes, alliteration, personification, hyperbole and many more. You will need a hi-lighter marker, blue/black pen(s), pencil and white-out (optional) Grade 11 Exam Practice Questions.

June Comprehension Exam. Grade 11 Words Project. February 24, 2012 - Words Work Period 2. March 6, 2012 - Words Work Period 3. March 7, 2012 - DUE DATE. March 7-8, 2012- Presentation Days.

Before you begin the writing process, you need to think about your Writing Variables. What type of jim crow laws time, piece are you writing? (Form) What is your theme or main message? (Central Idea) Who are you writing this for? (Audience) What is your reason for writing it/What are you trying to do? (Purpose) Where will your audience view, read or hear it? (Context) Persuasive Writing Assignments - Cyber Bullying and Topic of Choice. is not a problem that needs to be addressed in schools or in society as a whole. To assist you with your Macbeth Editorial Assignment and in addition to theory posting the newest assignment (first link), I have included two more files that contain writing strategies and tips for editorial writing. Rogerian Therapy! If you are still struggling with this assignment, please e-mail me or see me before/after class for clarification. The Lovely Bones vs. Tuesdays with Morrie Persuasive Essay Assignment. Due: Friday, December 21, 2013. To help you navigate your way through this assignment, I have included a couple of resources to assist you with writing a basic 5 paragraph essay.

Click on the links and or files below to humanistic access these resources. I also have some essay outlines and planners in the classroom, they are located in the black drawer in the back of the and times of william shakespeare, room. Please see me in class or e-mail for more information. Humanistic Theory! Immediately following this post you will find a file link for the CONNECTING YOUR WRITING VARIABLES Sheet. Please ensure that you hand in this along with your Persuasive Essay. The Lovely Bones: First Thoughts Reflection. In a reasonably sized paragraph, write down your first thoughts in your reflection journals after reading Chapter 1 in period The Lovely Bones.

You will be making regular comments and reflections in your journal throughout the novel study. Humanistic Psychology Theory! Please make sure you keep up to date with all entries. Monster by Walter Dean Myers. The Pigman by skater poem, Paul Zindel. A Glimpse into the Future (or the humanistic psychology, Present) Is Your Life Affected by Someone's Drinking? Jim Carroll and life and times of william, The Basketball Diaries. What did you learn from Jim Carroll's personal narrative? Was the psychology theory, diary form an effective way of telling a story?

Explain why or why not using references from the film.

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Essay: Hepatoprotective, liver disease, Hepatocytes. The liver is the principal organ for psychology theory, maintaining the bodys internal environment and so much water it plays a role in the metabolism of carbohydrate, proteins and fats, control the psychology theory, flow of nutrients, It is also the major reticulo- endothelial organ in the body as such has an important immune function in copper sulphate, maintaining body authenticity. Psychology Theory! It is helpful in, disposition of exogenous toxins or therapeutic agent, biochemical reaction. Hepatotoxicity is produced due to chemicals. Like synthetic (CCl4, Galactosamine, Lithocholic acid and define validity in research Anti-TB drugs), Natural (microcystins) and humanistic psychology Herbal remedies (Cascara sagrada) can also induce hepatotoxicity. In this review some of the plants with their extract studied for the protective effect in so much water close, liver diseases were summerised along with isolated compounds like Andrographolide, neoandrographolide, bacoside-A, colchicine, populnin, naringenin, echinacoside, kolaviron, ternatin, indigtona, rubiadin, bacicalein, baicalin, wogonin, punicalagin, punicalin for their hepatoprotective activity. Key word:- Hepatoprotective, liver disease, Hepatocytes. The liver is the largest organ of the humanistic psychology theory, body and it performs hundreds of rogerian critical functions to maintain homeostasis and psychology health.

These functions include production of skater poem serum proteins and hormones, detoxification of foreign and naturally occurring chemicals, glucose and lipid metabolism, etc. because of this many functions the liver diseases severely affect health and can be life threatening. There are four major types of liver disease, cirrhosis, fatty liver, hepatitis and liver cancer, from this heaptais and psychology liver cancer being among the most serious global public health problems.Hepatitis means inflammation of the liver in Latin, and the most common etiologies are infections by skater poem, one of five viruses, called hepatitis A, B, C, D and E. All of these viruses can cause acute diseases with symptoms lasting several weeks, including yellowish skin and eyes (jaundice), dark urine, extreme fatigue, nausea, vomiting and theory abdominal pain. However, Hepatitis B and C viruses can also establish persistent infections and thereby cause chronic hepatitis.1. More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Hepatotoxicity and drug-induced liver injury also account for rogerian, a substantial number of compound failures, highlighting the need for drug screening assays, such as stem cell-derived hepatocyte-like cells, that are capable of detecting toxicity early in the drug development process. Psychology Theory! Drug metabolism is crystals usually divided into two phases: phase 1 and phase 2. Phase 1 reaction is psychology thought to define validity, prepare a drug for psychology, phase 2. However, many compounds can be metabolized by phase 2 directly.Phase 1 reaction involves oxidation, reduction, hydrolysis, hydration and many other rare chemical reactions. These processes tend to water, increase water solubility of the drug and humanistic theory can generate metabolites that are more chemically active and potentially toxic. Skater Poem! Most of phase 2 reactions take place in the cytosol and humanistic theory involve conjugation with endogenous compounds via transferase enzymes.

Chemically active phase 1 products are rendered relatively inert and suitable for elimination by this step. A group of enzymes located in copper sulphate crystals, the endoplasmic reticulum, known as cytochrome P-450, is the most important family of metabolizing enzymes in psychology theory, the liver. Water Close! Cytochrome P-450 is the terminal oxidase component of an theory electron transport chain. Rogerian! It is not a single enzyme, but rather consists of psychology a closely related family of 50 isoforms; six of crystals them metabolize 90% of drugs. Humanistic Theory! There is a tremendous diversity of individual P-450 gene products, and skater poem this heterogeneity allows the liver to psychology theory, perform oxidation in a vast array of chemicals (including almost all drugs) in phase 1. Three important characteristics of the life and times shakespeare, P450 system have roles in drug-induced toxicity: 1. Humanistic Psychology! Genetic diversity: Each of the P-450 proteins is life and times of william unique and psychology accounts (to some extent) for the variation in drug metabolism between individuals.

Genetic variations (polymorphism) in P-450 metabolism should be considered when patients exhibit unusual sensitivity or resistance to drug effects at normal doses. Such polymorphism is also responsible for making sulphate crystals, variable drug response among patients of differing ethnic backgrounds. Cytochrome P-450 enzyme induction and inhibition. Potent inducers Potent inhibitors Substrates. 2. Change in psychology, enzyme activity: Many substances can influence the P-450 enzyme mechanism. Drugs interact with the enzyme family in several ways. Life And Times Shakespeare! 11 Drugs that modify cytochrome P-450 enzyme are referred to as either inhibitors or inducers. Enzyme inhibitors block the metabolic activity of one or several P-450 enzymes. Psychology! This effect usually occurs immediately.

On the other hand, inducers increase P-450 activity by validity, increasing its synthesis. Depending on the inducing drugs half life, there is humanistic psychology usually a delay before enzyme activity increases. 3. Competitive inhibition: Some drugs may share the same P-450 specificity and making copper sulphate thus competitively block their bio transformation. Humanistic! This may lead to jim crow time, accumulation of drugs metabolized by the enzyme. Humanistic! This type of drug interaction may also reduce the sulphate crystals, rate of generation of toxic substrate.

ETIOLOGICAL FACTORS FOR HEPATOTOXICITY. When the drugs administered orally or intravenously are focus to first pass metabolism in the liver which causes their biological inactivation. When the drug leaks first pass metabolism its biological activity maintains. Due to the absences of P450s and hepatic metabolic inactivation a stage will come when there is a prolonged response to a drug takes place .The presence of humanistic psychology P450 in liver can have a major influence on the efficacy and toxicicity of water close a drug. Several of the xenobiotics metabolizing P450 including CYP2A6, CYP2C9, CYP2C19and CYP 2D6, with the exemption of CYP2A6 that are having the capability to activate certain nitrosamine. From human liver specimens studies, it was concluded that there is still a high degree of humanistic psychology difference in their expression. When a limited number of P450s are involved in xenobiotics metabolism, Several P450s are involved in define, the synthesis of psychology steroid hormones. Copper! When P450s is activating several genes like CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1 is involved in the process. Drug interactions occur when two drugs are co administered and both are processed by the same P450.

One drug can then inhibit the metabolism of another drug significantly to high serum levels and prolonged biological activity and occasionally toxicity. This depends on psychology the drug activity as either inducer or inhibitor. So Much Water! When the effect is immediate, several P450 enzymes block metabolic activity. Psychology! On the other hand enzymes inducers chemical drug increase P450 activity by cumulative its synthesis. Life And Times Shakespeare! Other factors are:- Inherited birth imperfections.

Alcohol or poisoning by toxins. Certain medications that are toxic to the liver. Mechanism of Hepatotoxicity Caused By Different Agents. Several mechanisms are responsible for inducing hepatic injury. Many chemicals damage mitochondria, an theory intracellular organelle that produces energy. Time! Its dysfunction releases excessive amount of theory oxidants which in turn injures hepatic cells. Activation of some enzymes in rogerian therapy, the cytochrome P-450 system such as CYP2E1 also leads to oxidative stress. Injury to hepatocyte and bile duct cells lead to accumulation of bile acid in theory, liver. This endorses further liver damage.

Non-parenchyma cells, such as Kupffer cells also have a role in making copper sulphate crystals, the mechanism of hepatotoxicity. The liver injury involves two pathways direct hepatotoxicity and adverse immune reactions. Direct Hepatotoxicity: Drug induced liver injury is humanistic psychology originated by the bio activation of drugs to chemically reactive metabolites, which have the ability to interconnect with cellular macromolecules such as proteins, lipids, and nucleic acids, leading to protein dysfunction, lipid per oxidation, DNA damage, and jim crow time period oxidative stress. These reactive metabolites may induce interruption of humanistic psychology theory ion gradients and in research intracellular calcium stores, resulting in mitochondrial dysfunction and humanistic theory loss of energy production. This damage of cellular function can dismiss in making copper sulphate, cell death and likely liver failure. Immunological Reaction: liver cell dysfunction and cell death also have the ability to humanistic theory, produce immunological reactions, including both innate and so much adaptive immune responses. Damaging hepatocyte result in the activation of theory innate immune system like Kupffer cells, natural killer cells result in producing proinflammatory mediators and secreting chemokine to further recruit inflammatory cells to jim crow time, the liver.

It has been confirmed that various inflammatory cytokines, such as tumor necrosis factor (TNF) -Alfa, interferon (IFN) gamma, and interleukin (IL)-1beeta produced during drug induced liver injury are involved in promoting tissue damage. Innate immune cells are also the main source of IL-10, IL-6, and convinced prostaglandins, all have been shown to display hepatoprotective role.6 It is the subtle equilibrium of inflammatory and hepatoprotective mediators produced after activation of the humanistic psychology theory, innate immune system that determines an water individual susceptibility and adaptation to humanistic psychology, drug induced liver injury. The major procedures of drug induced liver injury include acute hepatitis, Cholestasis, and jim crow laws period a mixed pattern. These are the humanistic theory, factors influencing drug induced hepatotoxicity. Like Age,Ethnicity #038; race,Gender,Nutritional status,Underlying liver disease,Renal function,Pregnancy,Duration and dosage of so much water to home drug,Enzyme induction and Drug to drug interact. Development of humanistic theory liver injury takes place in three stages i.e. necrosis, fibrosis and cirrhosis. Rogerian! Cirrhosis of the liver is one of the major health problems in developed countries.

Although extensive work is being done in the field of cirrhosis the molecular mechanisms leading to humanistic psychology theory, cell death and increased collagen accumulation is still not clear. Therefore, treatment and jim crow period prevention of the psychology theory, cirrhotic process are still elusive. Most of the hepatotoxic chemicals damage liver cells mainly by inducing lipid peroxidation and other oxidative damages in liver. Toxic effects of drugs on the liver or its function may mimic almost every naturally occurring hepatic disease. Close! Their classification accords with that for adverse effects of drugs on the body in general, namely. Type A (Augmented) Liver injury occurs as the humanistic psychology theory, dose of jim crow laws period some drugs is raised causing. Centrizonal necrosis with paracetamol and also caused by carbon tetrachloride.

Hepatocelluar necrosis with salicylates. Fatty change in liver cells and cells and hepatic failure with tetracycline. Hepatitis with alcohol. Many drugs can cause hepatic damage at therapeutic doses. Acute hepatocellular necrosis.(General Anesthetics like halothane) Anticonvulsants (phenytoin, phenobarbitone) Cholesatic hepatitis (Phenotiazine, Chlorpromazine) Type C (Continued use) Chronic active hepatitis ( Isoniazide Methyldopa) Hepatic fibrosis or cirrhosis( Alcohol, Mthotrexate)

Type D (Delayed effect) Benign liver tumors may develop. When synthetic androgens (anabolic steroids) usually in high dose. Oral contraceptives are used for more than 5 years. Some Models To Screen Hepatotoxicity. Hepatotoxins are generally causes the necrosis, cirrhosis, carcinogenesis and hepatobilary dysfunction in theory, experimental animal. The following are some of the experimental models explained by employing some of the important hepatotoxins. a) Carbon tetrachloride model:- Acute liver damage caused by oral or subcutaneous administration of CCl4 dose of about 1.25mg/ml.

The maximum elevation of biochemical parameters is found within 24 hours after CCl4 administration normally administered as 50%v/v solution in liquid paraffin or olive oil. Chronic reversible hepatic damage cases when administration of CCl4 of define dose 1 ml/kg subcutaneously twice a week for humanistic psychology, continues 8 weeks. Chronic irreversible hepatic damage causes when administration of CCl4 of dose 1ml/kg for twice continuously 12 weeks. b) Paracetamol model: IT produces dose dependant hepatotoxicity through different routes of administration like the 800 mg/kg dose of paracetamol intraperitonially cause centrilobular necrosis without steatosis, a single dose of validity in research 3 g/kg leads to the acute hepatic damage within 48 hours. c) Chloroform model: it produces hepatotoxicity by inhalation or by subcutaneous route when the dose of 0.4 to 1.5ml/kg administered. d) Ethanol model:- it produces dose dependent hepatotoxicity a single dose of ethanol about 1ml/kg induces fatty degeneration, an administration of 40% v/v ethanol 2ml/100g/day for psychology, 21 days produces fatty liver. Skater Poem! The administration of the country made liquor 3ml/100g/day for 21 day produces liposis.

e) D-galactosamine model: it produces hepatotoxicity when a dose of 800mg/kg intraperitonially after 48 hours of administration by causing diffuse necrosis and steatosis. f) Thioacetamide model: it produces hepatotoxicity when the 100mg/kg subcutaneous dose administration it requires 48 hours by causing sinusoidal congestion and hydropic swelling with increase mitosis. g) Lithocholic acid models: These models generally used for Cholestasis liver injury, it produces Cholestasis when a dose of 4??mol/100gof body weight administered intravenously. h) Antimicrobial drug models:- Dose of antitubercular drug (Isoniazid 7.5mg/kg, rifampicin 10mg/kg, pyrazinamide 35 mg/kg, p.o.) for humanistic psychology, 2 weeks40. Dose of antitubercular drug (isoniazid 27mg/kg/day, rifampicin 54mg/kg/day, pyrazinamide 135mg/kg/day p.o.) administrated for 30 days, dose extrapolated from daily human dose using the conversion table based on body surface area. The dose of antitubercular drug (isoniazid and rifampicin 200mg each/kg body weight/day, p.o.) for 45 days. i) Azathioprine induced hepatotoxicity: This drug used in the therapy of autoimmune disorder and prevent graft rejection.

j) Ranitidine induced Hepatotoxicity: Liver injury induced by ranitidine is due to so much close to home, its metabolite which may lead to hepatic oxidative damage and one of humanistic its metabolite is generating immunoallergic reaction. Water Close! It also produces a reaction as reflected by humanistic psychology theory, infiltration of hepatocyte with ranitidine dose of either 50 or 30 mg/kg. k) Mercury induced hepatotoxicity: Dose of mercuric chloride: 5mg/kg body weight, through intra peritoneal injection for twenty days. Mercuric chloride dose: 2mg/kg body weight, administrated orally for thirty days45. l) Lead induced hepatotoxicity: Oral treatment with lead nitrate at a dose of validity in research 50mg/kg body weight daily for 40 days. m) Bromobenzene induced hepatotoxicity: (0.5, 2.0 and 5.0mmole/kg body weight, dissolved in corn oil, 40%v/v) administered orally for 10 12 weeks. Evaluation of Hepatoprotective Activity. The literature revel that several chemical substances and drugs having specific actions on liver are used as hepatotoxins in animals to generate the humanistic psychology theory, diseased conditions. In all test model systems, conditions for liver damage are implemented and an attempt is made to validity, counteract these toxicities with the substance under test. Humanistic Psychology Theory! The protective effect can be measured by estimating the enzyme activity and the rate of survival verified by histological method.

The available method is in-vivo, ex vivo, and in vitro methods. a. In-vivo methods: This method used to study the nature of giving compound and mechanism of the toxicant. Hepatotoxicity is and times shakespeare produced by in experimental animal by the administration of a known dose of psychology theory hepatotoxins like CCl4, galactosamine, Thioacetamide, ethanol and paracetamol etc.which causes marked measurable effects, the magnitude of which can be measured by jim crow laws, carrying out various liver function test like morphological, fuctional, biochemical and histopathological determinations. These methods are very convenient laboratory method. In this method reproducibility of the result is very poor. b. In vitro methods:- hepatocyte are generally isolated by using in-situ, two step recirculation collagens perfusion technique.

These seeded in small container and expose to test sample and toxins. After particular time period, the degree of toxicity assed by viability tests and humanistic theory enzyme levels such as SGOT, SGPT, ALP, Total protein, bilirubin and Cholesterol. c. Ex-vivo:- in this after completion of preselected in vivo test protocol hepatocyte are isolated and time period the percentage of viable cells and biochemical parameters are determined as a liver function testes. Theory! These methods are somewhat better correlated to clinical models than in vitro or in skater poem, vivo methods. Pharmacotherapy for Hepatotoxicity: In recent years the use of herbal drug for the treatment of psychology theory liver diseases has increased all over the world because of jim crow time period herbal drugs are believed to be harmless and free from serious adverse reactions as they are obtained from nature and are easily available. Humanistic! Apart from that larger number of drugs of plant origin are endowed with hepatoprotective claims directly or indirectly.

Many research has examined the effects of plants used traditionally by many traditional remedies from plant origin have been used for the treatment of liver diseases. In most cases, research has confirmed traditional experience and wisdom by jim crow, discovering the mechanisms and mode of action of these plants as well as re affirm the therapeutic effectiveness of certain plants or plant extracts in clinical studies. Several hundred plants have been examined for psychology theory, use in a wide variety of liver disorders. Just a handful has been fairly well researched.There are about 600 commercial herbal formulations, which are claimed to have hepatoprotective activity and water close many of them are being sold in humanistic theory, markets all over the world. In India, about 40 patented polyherbal formulations representing a variety of rogerian combinations of 93 herbs from 44 families are available Liver protective herbal drugs contain a variety of humanistic theory chemical constituents like phenols, coumarins, lignans, essential oil, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthone derivatives. Some of the polyhebral formulations are verified for their hepatoprotective action against chemically induced liver damage in experimental animals: Liv.52, Liv.42, Liver cure, Tefroli, Livol , Hepatomed ,Jigrine , Stimuliv , Koflet and Icterine. In present urosodeoxycholic acid is only one allopathic compound approved by and times of william, US FDA for treatment of primary biliary cirrhosis or hepatoprotection.it is humanistic psychology used to in research, treat all Cholestasis conditions because it improves serum level. Clinical Uses of UDCA. 1. Biliary cirrhosis. 2. Biliary disease secondary to cystic fibrosis.

3. Non-alcoholic steatohepatitis, idiopathic chronic hepatitis. 4. Autoimmune hepatitis. 5. Primary sclerosing cholangitis. 6. Alcoholic hepatitis. List of some medicinal plant which shows hepatoprotective activity. Plant Botanical name with family Screening models Extract used Plant part Ref.

Accacia catechu Leguminose Carbon tetrachloride induces Ethyl acetate Powder pale catechu 45. Aegle marmelos Rutaceae Paracetamol induces Ethanol Fruit pulp 46. Aerva lanata linn. Amaranthaceae Paracetamol induces Hydro alcoholic Coarse powder 47. Annona squamosa linn. Annonaceae Isoniazide + rifampicin Alcoholic Leaves 48.

Alocasia indica linn. Araceae Paracetamol induces Hydro alcoholic Leaves 49. Annonaceae Carbon tetrachloride induces Hydro alcoholic Bark 50. Liliaceae Carbon tetrachloride induces Aqueous extract Dried areal part 51. Azardirachta indiaca linn. Meliaceae Paracetamol induced Ethanol Leaf 52.

Nyctaginaceae Thioacetamide Aqueous Roots 53. Capparaceae Carbon tetrachloride induces Aqueous and methanolic Stems 54. Bixa orellana Bixxaceae Carbon tetrachloride induces Methanolic Plant material 55. Cajanus scarabaeoide Fabaeceae. Paracetamol induced 84 Ethanol Whole plant 56.

Carissa carindas Linn Apocyanaceae. Carbon tetrachloride induces 85 13 Ethanol Root 57. Carum copticum Apiaceae Carbon tetrachloride induces, paracetamol 86. Aqueous methanolic extract Seed 58. Calotropis procera Asclepediaceae Carbon tetrachloride induces 87. Ethanol Root bark 59.

Cassia fistula Leguminosae Carbon tetrachloride induces 88. Methanolic Leaf 60. Carbon tetrachloride induces Aqueous and. Asteraceae Paracetamol Aqueous. Ethanol Fresh plant 62. Decalepis hamiltonii Asclepiadaceae Carbon tetrachloride induces 99. Aqueous Roots 63. Equisetum arvense equisetaceae Carbon tetrachloride induces 101. Metahnolic Aerial parts 64. Embelia ribes myrsinaceae Paracetamol induced 102.

Water Fruits 65. Enicostemma axillare Gentianaceae D-galactosamine 103 Ethanol Whole plant 66. Ginkgo biloba Ginkgoaceae Carbon tetrachloride induces 109. Ethanol Dried extract 67. Glyrrhiza glabra Fabaceae Carbon tetrachloride induces 110. Crude drug Root powder 68. Hibiscus Sabdariffa Malvaceae Paracetamol induced 115. Water Leaves 69. Hypericum japonicum Clusiaceae Carbon tetrachloride induces 117. Water Whole plant 70.

Carbon tetrachloride induces Hydroalcoholic Leaves 71. Plumbaginaceae 35 Carbon tetrachloride induces Methanolic Aerial part 72. Carbon tetrachloride induces Ethanol Leaves 73. Carbon tetrachloride induces Ethanol Leaves 74. Carbon tetrachloride induces Petroleum ether, And methanol Whole. Anacardiaceae 39 Carbon tetrachloride induces Methanolic Stem 76. Ocimum sanctum Lamiaceae 135. Paracetamol induced Hydroalcoholic Leaf 77. Orthosiphan stamineus Lamiaceae 136 Acetaminophen Methanol.

Oroxylum indicum linn. bignoniacec Carbon tetrachloride induces Ethanol Leave 79. Phyllanthus amarus schum Euphorbiaceae 137. Ehanol Ethanol Aerial part 80. Phyllanthus amarus Euphorbiaceae 138 Aflatoxin b1 induced liver. Ethanol Whole plant except root 81. Picrorhiza kurrooa Scrophulariaceae 142. Alcohol carbon tetra chloride Ethanol Root and rhizomes 82.

Picrorrhiza rhizome Scrophulariaceae 143. Poloxamer(PX)-407 Water Dried underground stem 83. Piper chaba Piperaceae 144. D-galactosamine Aqueous acetone Fruit 84. Piper longum Piperaceae 145.

Carbon tetrachloride induces Milk extract Fruits and roots 85. Pittosporum neelgherrense Pittospoaceae. Methanolic Stem bark 86. Pterocarpus marsupium Papilionaceae 148. Carbon tetrachloride induces Methanol and aqueous Stem bark 87. Plantago major Plantaginaceae 147. Carbon tetrachloride induces Ethanol Seeds 88. Ptrospermum acerifolium Sterculiaceae 149. Carbon tetrachloride induces Ethanol Leaves 89. Ricinus communis Euphorbiaceae 150. Carbon tetrachloride induces Cold aqueous extract Leaves 90.

Sarcostemma brevistigma Asclepiadaceae 152. Carbon tetrachloride induces Ethyl acetate Stem 91. Saururus chinensis Sauruaceae 153. Carbon tetrachloride induces Ethanol Whole plant 92. Scoparia dulcis Scrophulariaceae 154.

Carbon tetrachloride induces Methanol,diethyl ether,pt.ether Whole plant 93. Solanum nigram Linn Solsnaceae 156. Carbon tetrachloride induces Aqueous -Methanol Fruits 94. Tecomella undulate Bignoniaceae 157. Thioacetamide Aqueous-ethanolic Stem, bark 95. Tephrosia purpurea Linn Fabaceae 158 Thioacetamide Aqueous -methanol Aerial parts 96. Thunbergia laurifolia Acanthaceae 159. Ethanol Aqueous extract Leaves 97. Tridax procumbens Asteraceae 160. Carbon tetrachloride induces Ethanol Leaves 98.

Tylophora indica Asclepiadaceae 161. Ethanol Methanolic Leaf powder 99. Vitex trifolia Verbenaceae 162. Carbon tetrachloride induces Ethanol and water Leaves 100. Vitis vinifera Vitaceae 163 Carbon tetrachloride induces Etylacetate n-butanol ,water Leaves 101. Hepatic diseases remains a major worldwide health problem thus the psychology theory, search of skater poem new medicine is still going many formulations of medicinal plants are used to treat liver disorder in Chinese ethno medical and traditional medicine practices. The goal of ethnopharmacological studies on humanistic psychology theory medicinal plants should not be restricted to find new prototype pure compounds as drugs. Active extracts or mixture of extracts may prove very effective drugs. Plant drugs for liver diseases should possess sufficient efficacy to skater poem, cure severe liver diseases caused by toxic chemicals, viruses, excess alcohol intake, and repeated administration of drugs like paracetamol, Rifampicin and Isoniazid.

Various herbal plants and psychology theory plants extracts have significant hepatoprotective activity in animal models was proved by research. Making Sulphate Crystals! The hepatoprotective activity of the plants probably due to humanistic theory, the presence of phenols, coumarins, lignans, essential oil, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthone derivatives. Effective formulations have to be developed using indigenous medicinal plants, with proper pharmacological experiments and clinical trials. The manufacture of plant products should be governed by standards of safety and efficacy. Along with all more allopathic drugs like urosodeoxycholic acid need to time, be develop for treatment of liver disease and hepatotoxicity. Search our thousands of essays: If this essay isn't quite what you're looking for, why not order your own custom Health essay, dissertation or piece of psychology theory coursework that answers your exact question? There are UK writers just like me on jim crow laws time hand, waiting to help you. Humanistic! Each of us is qualified to a high level in our area of expertise, and skater poem we can write you a fully researched, fully referenced complete original answer to humanistic psychology, your essay question. Just complete our simple order form and you could have your customised Health work in your email box, in as little as 3 hours. This Health essay was submitted to us by a student in define validity, order to help you with your studies.

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